Strange USB soundcard problem with aplay (on RPi3)

[Jon80]

Hi all!

I have some problems with a USB Soundcard, which have both an audio 3.5mm output and a microphone input.

If i try aplay, i get the error:

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set_params: 1239: Channels count non available

I have created a .asoundrc in /home/pi folder, but that didn't help.
The strange thing is that youtube works fine (on Chromeium-browser), and if i goto a WebRTC (http://www.jit.si) the microphone works, but not the headphone jacket on the USB soundcard.

I get no sound with neither WebRTC or aplay (I've checked so sound isn't passed through stardard 3.5mm jacket or HDMI)
If i try:

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aplay /usr/share/sounds/alsa/Front_Center.wav -D hw:<num>,<num>

That works well, and sound is passed thorugh USB Soundcard output.

Any ideas?