You've played Minecraft 4 player split screen? Have you played anything through Steam (that is where I have a problem I think)?
I am using Moonlight 2.0.2 (well I am building from source to be accurate). I'm assuming this Xbox 2.1 accessories are just drivers? Maybe I should checked mine.
Wired/wireless was in reference to the controllers not the internet connection. I am using two wired xbox controllers and 2 wireless (via a single receiver).
Cheers for your help though, don't suppose you have steam and can try a game or just launch the UI and see if all 4 controllers respond?
My controllers when connected to my PC use driver 220.127.116.119.