In times of cheap SSDs it's good that the Raspberry can boot from USB.
My Raspi has been running fine now for three weeks 7/24 an WD Green PC SSD WDS2 40G2G0A-00JH30 attached by an SATA USB3 Adapter with one USB cable (https://www.amazon.de/dp/B06XCV1W97)
The Raspi first would not boot and display only a blank screen. You have to enlarge the USB timeout:
https://www.raspberrypi.org/documentati ... ootflow.md