Not without some input from Skype (er, now Microsoft) to build a version for the Pi. I think. There may be a version for Arm, but I doubt it will connect to the video hardware as it stands. Might get away with voice calls.
Principal Software Engineer at Raspberry Pi (Trading) Ltd.
Contrary to popular belief, humorous signatures are allowed. Here's an example...
"My grief counseller just died, luckily, he was so good, I didn't care."