There's no real reason why it can't be used as long as you don't want to use the camera module - that uses the I2C-0 peripheral direct from the GPU, and there is no arbitration between the two processors.
Memory says that there are no pullups fitted to those pins, so you may need to fit your own.
Software Engineer at Raspberry Pi Trading. Views expressed are still personal views.
I'm not interested in doing contracts for bespoke functionality - please don't ask.