A switch has been added to the firmware driver to allow control of the on-sensor DPC. To use it, update the firmware via rpi-update, and run the following command before starting the camera:
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sudo vcdbg set imx477_dpc <value>
0 - All DPC disabled.
1 - Enable mapped on-sensor DPC.
2 - Enable dynamic on-sensor DPC.
3 - Enable mapped and dynamic on-sensor DPC.
The default is (3). It would be useful to get feedback from users who do astrophotography if disabling DPC actually makes a difference or not.
Note that this does not disable the ISP defective pixel correction that will still be active, so you will likely only see changes in the RAW image.