You need to power up your speaker i.e. audio amplifier with USB power i.e. 5VDC. There is only one limitations i.e. USB powered devices have very less current sourcing capabilities. If you are trying to power you amplifier module with USB power then you will only get few Watts of amplification i.e. the loudness of the sound will be small.
The following link will help you to do so.
http://www.instructables.com/id/USB-Pow ... /?ALLSTEPS
But the OPAMP used in the tutorial for amplification is not quite stable and will even induce noise on high pitch. But the tutorial will give you some idea of your idea implementations. For better implementations go for 5VDC audio Amps of 3Watts max. these are readily available with manufacturers like Philips etc.