I've been using Karrigell for many years now. There's version 3.1.1 for Python 2.x and version 4 for Python 3.
Very easy to learn, but powerful nevertheless. User management (including different roles), support for different kinds of data bases, RSS feeds, email, a simple templating system and much more.
On real internet servers I use it in proxy mode behind lighttpd; for in house applications I use the built-in threaded web server.
Minimal Kiosk Browser (kweb)
Slim, fast webkit browser with support for audio+video+playlists+youtube+pdf+download
Optional fullscreen kiosk mode and command interface for embedded applications
Includes omxplayerGUI, an X front end for omxplayer