Pygame, Pyglet, Pyopengl, SDL2 have been my starting points.
is getting tweaked for Pi4's.
Even shaders can be done now, I started here.
OpenGL is easier on the Pi4, it mostly just works.
It is not perfect and mesa3D 19.2.6 just got some more Pi commits.
I'm dancing on Rainbows.
Raspberries are not Apples or Oranges