No. There is no single library/solution in python to do video/audio recording simultaneously. You have to implement both separately and merge the audio and video signal in a smart way to end up with a video/audio file. Telldunkin Donuts I got a solution for the problem you present. My code addresses...

Yes, You would have individual control of each led (consider each shiftregister as 8 additional out pins)

There's lot's of code samples around for controlling shiftregisters.

Your biggest problem is going to be the wiring of 100 LED's...