ok /dev/ttyUSB_RELAY is the real device name? The same nane you used to check the serial adapter. Yes, the result is the same Could you add dsrdtr parameter into this line 31. self.port = serial.Serial('/dev/ttyUSB_RELAY', 19200, timeout=1, xonxoff=0, rtscts=0,dsrdtr=0) Does the led flicker when yo...